Heemstra Lab 

Atwood 450

Department of Chemistry

Emory University

Website Designed by
Rachel and Misael

Small Molecule Detection and Sequestration

Water Purification using Aptamer-functionalized Membranes

Single Molecule Kinetics of Aptamer Based Biosensors

Toxin Sequestration using Aptamer Modified Virus-like Particles

Nucleic Acid-based Treatment of Organophosphate Poisoning

Nucleic Acid-Based Treatment of Organophosphate Poisoning

Nucleic Acid-Based Treatment of Organophosphate Poisoning

SELEX Selection for Aptamers with Diagnostic Applications

Relevant Publications

 

Tan, Z.; Heemstra, J. M. High-Throughput Small-Molecule Enantiopurity Measurement Using Flow Cytometry. ChemBioChem 2018  Accepted Article.

Tan, Z.; Feagin, T. A.; Heemstra, J. M. Temporal Control of Aptamer Biosensors Using Covalent Self-Caging to Shift Equilibrium. J. Am. Chem. Soc. 2016138, 6328-6331.

 

Meek, K. N.; Rangel, A. E.; Heemstra, J. M. Enhancing aptamer function via in vitro selection using modified nucleic acids.  Methods 2016 29-36.

Perera, R. T.; Fleming, A. M.; Peterson, A. M.; Heemstra, J. M.; Burrows, C. J.; White, H. S. Size-dependent unzipping of duplexes of A-form DNA-RNA, A-form DNA-PNA, and B-form DNA-DNA in the alpha-hemolysin nanopore. Biophys. J. 2016110, 306-314

Heemstra, J. M. Learning from the Unexpected in Life and DNA Self-Assembly. Beil. J. Org. Chem. 2015 11, 2713-2720.

Peterson, A. M.; Jahnke, F. M.; Heemstra, J. M. Modulating the Substrate Selectivity of DNA Aptamers Using Surfactants.  Langmuir 2015 31, 11769-11773.

Feagin, T. A.; Olsen, D. P. V.; Headman, Z. C.; Heemstra, J. M. High-Throughput Enantiopurity Analysis using Enantiomeric DNA-Based Sensors. J. Am. Chem. Soc. 2015 137, 4198-4206.

Peterson, A. M.; Heemstra, J. M. Controlling Self-Assembly of DNA-Polymer Conjugates for Applications in Imaging and Drug Delivery. WIREs Nanomed. Nanobiotechnol., 2015 7, 282-297.

Kent, A. D.; Spiropulos, N. G.; Heemstra, J. M. General Approach for Engineering Small-Molecule-Binding DNA Split Aptamers. Anal. Chem. 2013 85, 9916-9923.

 

Sharma, A. K.; Kent, A. D.; Heemstra, J. M. Enzyme-Linked Small-Molecule Detection using Split Aptamer Ligation. Anal. Chem. 2012 84, 6104-6109.

Sharma, A. K.; Heemstra, J. M. Small Molecule-Dependent Split Aptamer Ligation. J. Am. Chem. Soc. 2011 133, 12426-12429.

Toxin Sequestration with Aptamer Functionalized Membranes