Post-Transcriptional Modification


Chemical Biology Tools for Studying A-to-I RNA Editing

Probing the Ligandable Transcriptome

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Small Molecule Binding RNA Aptamer-Based Post-Transcriptional Regulation

Development of Tools to Study RNA Editing

Improved Mapping of A-to-I Editing Sites

Development of High-Throughput Screens to Study RNA foci Disruption

Relevant Publications


Hanson, W. M.; Chen, Z.; Jackson, L. K.; Attaf, M.; Sewell, A. K.; Heemstra, J. M.; Phillips, J. D. Reversible Oligonucleotide Chain Blocking Enables Bead Capture and Amplification of T-Cell Receptor α and β Chain mRNAs.  J. Am. Chem. Soc. 2016 138, 11073-11076.​

Perera, R. T.; Fleming, A. M.; Peterson, A. M.; Heemstra, J. M.; Burrows, C. J.; White, H. S. Size-dependent unzipping of duplexes of A-form DNA-RNA, A-form DNA-PNA, and B-form DNA-DNA in the alpha-hemolysin nanopore. Biophys. J. 2016110, 306-314

Sharma, A. K.; Plant, J. J.; Rangel, A. E.; Khoe, K. N.; Anamisis, A. J.; Hollien, J.; Heemstra, J. M. Fluorescent RNA Labeling Using Self-Alkylating Ribozymes. ACS Chem. Biol. 2014 9, 1680-1684.